MuscleCoop

Retroceder   MuscleCoop > Nutrición

Respuesta
 
Herramientas Desplegado
Antiguo 24-Jun-2020, 22:29 #51
posavasos posavasos no está en línea


Más de 3.000 posts, señora. Qué le parece
 
Fecha de Ingreso: 08-October-2004
Mensajes: 3.523
Mentioned: 58 Post(s)
posavasos posavasos no está en línea


Más de 3.000 posts, señora. Qué le parece

 
Fecha de Ingreso: 08-October-2004
Mensajes: 3.523
Mentioned: 58 Post(s)
Predeterminado

Cita:
Direct research on vitamin D and Covid

Peer Reviewed
- A Mendelian randomisation analysis of excess COVID-19 mortality of African-Americans in the US suggests that vitamin D is a risk factor for Covid Mortality
- A review of the evidence finds that supplementing with vitamin D in accordance with government guidelines is a good idea, but there is no evidence to support supplementation rates higher than 4,000 IU/day

Preprint
- A re-analysis of 107 Swiss blood samples found that PCA positive patients had 25-hydroxyvitamin D concentrations half that of PCA negatives. This finding held after stratifying for age and gender.
- A restrospective study in the Philippines found a significant association between vitamin D status and severe Covid-19 infections.
- An Indonesian study of 780 people found that after controlling for age, gender, and co-morbidity, vitamin D deficiency was associated with a twelve times higher risk of death.
- Hospitalized male Covid-19 patients were found to have lower vitamin D levels than controls
- A study out of Northwestern University found that the vitamin D status of a country's elderly population was associated with the number of severe cases of Covid-19 in that country.
- A retrospective cohort study found that Chicago patients who were likely vitamin D deficient were more likely to test positive for Covid-19.
- A observational study from Belgium found that vitamin D deficiency is correlated with the risk for hospitalization for COVID-19 pneumonia and predisposes to more advanced radiological disease stages.
- A small cohort trial found that just 16% of patients who received vitamin D, magneseum, and vitamin B12 required oxygen compared with 61.5% of the previous cohort who did not receive DBM supplementation.


Comprehensive debate by the Irish Medical Journal:
- Covid-19, Cocooning, and Vitamin D Intake Requirements Link
- Authors of Article ‘Optimisation of Vitamin D Status for Enhanced Immuno-Protection against Covid-19’ by McCartney et al. comment on response report‘Covid-19, Cocooning and Vitamin DRequirements’ by McKenna et al Link
- Vitamin D and Inflammation: Potential Implications for Severity of Covid Link
- Authors of Article ‘Optimisation of Vitamin D Status for Enhanced Immuno-Protection against Covid-19’by McCartney et al. comment onresponse letter ‘Vitamin D and Covid-19: A Note of Caution’ by Rabbitt et al.Link
- Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection Link

Lit reviews and clinical guidance
- This review of potential vitamin D mechanisms of action provides some useful history on the origin of vitamin D dosing recommendations. They also review their clinical guidelines after treating several thousand patients with 5000-10000 IU/day, including recognizing and resolving hypercalcemia or other adverse events.
- Slovenia has begun administering vitamin D to residents of nursing homes and health care workers.
- A review in Nature suggests that all patients should be monitored and potentially treated for vitamin D deficiency.
- A bmj report which is generally critical of the connection between Covid-19 and vitamin D nevertheless concludes that supplementation according to government health guidelines (no more than 4,000 IU/day) is sensible for most people.
- Evidence supports a vitamin-D causal model more than an acausal one.
- A quarantine hospital in Egypt has started providing vitamin D to frontline medical workers.
- The French National Academy of Medicine now recommends vitamin D supplementation as a prevantive and adjuvent therapy for Covid-19 infection.

Vitamin D / Covid correlations
- Vitamin D deficiency is very common in places that have been hit hard by the disease.
- Vitamin D reduces the risk of thrombosis which is one of the puzzling symptoms of Covid-19
- Kawasaki disease was weakly associated with vitamin D supplementation at birth and KD patients had lower levels of vitamin D. There is an association with Covid-19 and a syndrome similar to Kawasaki disease in children.
- People with the genetic condition phenylketonuria tend to consume a diet fortified with vitamin D, and anecdotally have not suffered any Covid-19 deaths.
- Hypocalcemia was associated with covid-19 severity. Vitamin D deficiency is one cause of hypocalcemia.

Race and Covid
- Black and Asian populations are at a high risk of Covid morality. Some studies have found a relationship between skin pigmentation an vitamin D levels, but others have found that there is no difference in bio-available vitamin D because of differences in genetic polymorphisms related to vitamin D–binding protein. Interestingly, vitamin D binding protein is itself associated with infectious lung diseases.
- There are lots of other factors) which vary by race and which make Covid mortality more likely. These do not fully explain the race gap.
- BAIPO, which represents UK doctors of Indian origin wrote to the NHS advocating for vitamin D testing and supplementation for front line staff. They are providing all members with vitamin D on request.
- Blacks/African Americans are 5 Times More Likely to Develop COVID-19: Spatial Modeling of New York City ZIP Code-level Testing Results
- Excess African-American mortality in the US was higher in southern states than northern states.
- A dataset of 6 million US veterans found that black and hispanic had higher rates of Covid-19 which were not explained by medical conditions or where they live or receive care.
- An analysis found that immigrants to Sweden from low and middle income countried were 1.5-2.5 times more likely to die from Covid.
- BAME children at at a higher risk for PIMS-TS in Paris and London.
- An analysis of census data found that for all minorities, the minority's population share is strongly correlated with total COVID-19 deaths.

Supplementation in the absence of evidence
- Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths
- Nature - Perspective: Improving vitamin D status in the management of COVID-19
- COVID-19 Perfect Storm (Part II): Role of Vitamins as Therapy or Preventive Strategy in Aged People


Latitude and UVB radiation
- UVB radiation, which the skin uses to manufacture vitamin D is associated with lower death rates and case fatality rates.
- Covid-19 deaths-per-million appears to vary by latitude.
- Latitude was not associated with a proportional increase in cases during one week of March.
- Latitude is a significant predictor of covid mortality after controlling for age.

Potential Mechanisms

- This is the best overview of potential vitamin D mechanisms with respect to Covid-19.
- Vitamin D helps regulate the renin angiotensin system which includes the ACE2 receptor that Covid-19 binds to.
- Vitamin D may bind to the non-structural protein nsp7 on the SARS-CoV-2 virus.
- An article in Nature outlines a number of potential mechanisms.
- The Essential Role of Vitamin D in the Biosynthesis of Endogenous Antimicrobial Peptides May Explain Why Deficiency Increases Mortality Risk in COVID-19 Infections
- Vitamin D is essential to the formation of antimicrobial peptides such as cathelicidin and beta defensins.
- Lungs as Target of COVID-19 Infection: Protective Common Molecular Mechanisms of Vitamin D and Melatonin as a New Potential Synergistic Treatment
- Calcitriol, the active form of Vitamin D is active against the SARS-COV2 virus.

Vitamin D background and previous studies
- Vitamin D reduces the risk of other acute respiratory infections. One interesting finding of this meta-analysis is that people who were very deficient (less than 25 nmol/L) saw the largest protective effect with an adjusted odd ratio of 0.58 and a 95% CI of 0.40 to 0.82. These are the same populations which seem to be at risk for severe Covid-19.
- Vitamin D and Influenza — Prevention or Therapy?
- Vitamin D and the anti-viral state
- Vitamin D Supplementation to Prevent Acute Respiratory Tract Infections: Systematic Review and Meta-Analysis of Individual Participant Data

Studies refuting evidence of benefits
- Vitamin D levels between 2006-2010 were associated with Covid-19 mortality, but not after controlling for every other variable in the data set. I don't know what to do with this study because there's a causal story in which low vitamin D in 2010 _increases_ vitamin D in 2020 because that group is likely to supplement.
https://github.com/GShotwell/vitamin_d_covid

Evidence Supports a Causal Role for Vitamin D Status in COVID-19 Outcomes
https://www.medrxiv.org/content/10.1....01.20087965v3

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
https://www.frontiersin.org/articles...020.01451/full
posavasos no está en línea   Responder Citando
Antiguo 25-Jun-2020, 05:14 #52
Avatar de morboh
morboh morboh no está en línea
Cooperador



Más de 10.000 posts: Accionista de MuscleCoop

 
Fecha de Ingreso: 31-December-2008
Mensajes: 13.476
Mentioned: 14 Post(s)
morboh morboh no está en línea
Cooperador



Más de 10.000 posts: Accionista de MuscleCoop


Avatar de morboh
 
Fecha de Ingreso: 31-December-2008
Mensajes: 13.476
Mentioned: 14 Post(s)
Predeterminado

Cita:
Iniciado por Rastas^ Ver Mensaje
Hola. Sí, así es, por mi trabajo o el que era mi trabajo no me compensa ya buscar volumen. Después de 25 años entrenando y siempre que siga haciéndolo mantengo un volumen podríamos decir "natural" en mí, set point o como se quiera llamar, lo que mi cuerpo mantiene con el estímulo de entrenamiento. Respecto al brazo, por ejemplo oscilo entre 41/42 centímetros dependiendo de lo seco o tapado que esté, pero de ahí no me muevo ni para arriba ni para abajo. E intentar subir de volumen me supone una tortura tal, teniendo que dar 12/15 clases aeróbicas semanales que ya no me compensa, hace mucho que tiré la toalla. Aparte no me veo mal del todo para 43 años que voy a hacer.

Y en lo de la definición estoy contigo. Tampoco sé por qué ocurre, incluso intentando tomar la proteína en polvo o aminos lo más limpios posibles, sin edulcorantes como dices ni nada, pero fue quitarlos y sí mejorar en definición, un poco más seco como estado normal y no he perdido volumen, o no reseñable, con lo cual a mí no me compensa, aparte del ahorro económico y el quitarme de la cabeza qué proteína compro, de qué marca, qué tipo, si merece la pena un hidrolizado, si tal concentrado es mejor que cual... todo esto ha supuesto un enorme alivio para mí.

Te sorprenderá, pero recuerdo aún perfectamente un post que subiste hará un cerro de años... 10 tal vez o más, por ahí... en el que decías que en naturales, y por mucho que apretaras la dieta no lograbas quitar la última película de grasa, sobre todo zonas resistentes junto a ombligo o zona lumbar (es más mi caso). Yo ya por aquel entonces barruntaba que el hecho de quitar la proteína en polvo o los suplementos en general mejorarían este aspecto en naturales, esa última capa de retención de grasa, líquidos o lo que sea que de otra forma no se van.

Entonces yo ya en su día elegí ese punto extra de sequedad y perder ese poco más de volumen que tampoco sé si me dan. Básicamente eso.

Deseo que estés muy bien.

Saludos.
Yo llevaba tiempo haciendo el pre ''ligero'' rollo meadows de la proteína... crema de arroz o copos de maiz y alguna grasa pre entreno, y tuve que ampliar el margen de tiempo y subir a 2 horas para tener esa comida más o menos asentada.

Ahora como arroz con pollo y un plátano y me da la sensación de que en una hora o menos podría estar entrenando.

Respecto al título del post... NO. No voy a meter suplementación especial por esta mierda.
morboh no está en línea   Responder Citando
Antiguo 25-Jun-2020, 08:17 #53
Avatar de Rastas^
Rastas^ Rastas^ no está en línea


¿Más de 5.000 posts?... ¡¡JUGÓN!!
 
Fecha de Ingreso: 03-September-2004
Mensajes: 5.576
Mentioned: 56 Post(s)
Rastas^ Rastas^ no está en línea


¿Más de 5.000 posts?... ¡¡JUGÓN!!

Avatar de Rastas^
 
Fecha de Ingreso: 03-September-2004
Mensajes: 5.576
Mentioned: 56 Post(s)
Predeterminado

Cita:
Iniciado por morboh Ver Mensaje
Yo llevaba tiempo haciendo el pre ''ligero'' rollo meadows de la proteína... crema de arroz o copos de maiz y alguna grasa pre entreno, y tuve que ampliar el margen de tiempo y subir a 2 horas para tener esa comida más o menos asentada.

Ahora como arroz con pollo y un plátano y me da la sensación de que en una hora o menos podría estar entrenando.

Respecto al título del post... NO. No voy a meter suplementación especial por esta mierda.
Hola. No sé por qué pero a mí me pasa igual, sí. Ya en su día quité todos los suplementos calóricos "líquidos", en teoría debería ser la digestión más rápida, en teoría, pero al menos en mi caso y a efectos prácticos hago mejor la digestión con sólidos. De hecho como digo intento ya evitar las proteínas líquidas o cualquier carbohidrato líquido, ni amilo ni ciclodextrinas ni nada, y, aparte de mejor aspecto, las digestiones son más rápidas en mí, me siento más ligero antes, cosa que agradezco, la verdad, me da mucha vida a la hora de entrenar.

Imagino que cada cuerpo y cada estómago es un mundo.

Saludos.
__________________
Karmapa Chenno.
Rastas^ no está en línea   Responder Citando
Antiguo 30-Jun-2020, 09:51 #54
Avatar de morboh
morboh morboh no está en línea
Cooperador



Más de 10.000 posts: Accionista de MuscleCoop

 
Fecha de Ingreso: 31-December-2008
Mensajes: 13.476
Mentioned: 14 Post(s)
morboh morboh no está en línea
Cooperador



Más de 10.000 posts: Accionista de MuscleCoop


Avatar de morboh
 
Fecha de Ingreso: 31-December-2008
Mensajes: 13.476
Mentioned: 14 Post(s)
Predeterminado

He vuelto a meter prote en polvo y gases etc...
morboh no está en línea   Responder Citando
Respuesta


(0 miembros y 1 visitantes)
 
Herramientas
Desplegado

Normas de Publicación
No puedes crear nuevos temas
No puedes responder mensajes
No puedes subir archivos adjuntos
No puedes editar tus mensajes

Los Códigos BB están Activado
Las Caritas están Activado
[IMG] está Activado
El Código HTML está Desactivado

Ir al Foro

 


La franja horaria es GMT. Ahora son las 16:36.


Powered by : vBulletin® Versión 3.8.11
Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
Traducido por mcloud de vBhispano.com
User Alert System provided by Advanced User Tagging (Lite) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
MuscleCoop © 2004 - 2019